@article{Reisbitzer2024,
title = {The Dynamic World of RNA: Beyond Translation to Subcellular Localization and Function},
author = {Annika Reisbitzer and Sybille Krauß},
editor = {Front. Genet},
doi = {10.3389/fgene.2024.1373899},
year = {2024},
date = {2024-03-12},
abstract = {RNA is a versatile and dynamic molecule that plays an important role in many aspects of cell biology and physiology. Its diverse functions reach from acting as a template for protein biosynthesis to a variety of regulatory, structural, and catalytic activities in the cell. Primary transcripts and processed RNAs are not randomly distributed in the cell but are found in specific subcellular compartments. This is particularly important in neurons, a highly polarized cell type. Several mechanisms are known to regulate RNA localization and transport, including passive diffusion, phase separation into RNA granules, and active transport. All these processes contribute to cellular RNA dynamics. Interestingly, these transport mechanisms are influenced by different regulatory elements of the RNA molecule itself, e.g., by alternative polyadenylation, or by the association with RNA-binding proteins (RBPs). Deregulation of these mechanisms is connected to pathogenic mechanisms that lead, for example, to neurodegenerative diseases.},
keywords = {neurodegenerative diseases},
pubstate = {published},
tppubtype = {article}
}