@article{Ballarin2024,
title = {A novel aurone RNA CAG binder inhibits the Huntingtin RNA–protein interaction},
author = {Giovanna Ballarin and Maddalena Biasiotto and Annika Reisbitzer and Marlen Hegels and Michael Bolte and Sybille Krauß and Daria V. Berdnikova},
editor = {RSC Medicinal Chemistry},
doi = {10.1039/d4md00403e},
year = {2024},
date = {2024-07-17},
journal = {RSC Medicinal Chemistry},
volume = {9, 2024},
abstract = {Huntington's disease (HD) is a devastating, incurable condition whose pathophysiological mechanism relies on mutant RNA CAG repeat expansions. Aberrant recruitment of RNA-binding proteins by mutant CAG hairpins contributes to the progress of neurodegeneration. In this work, we identified a novel binder based on an aurone scaffold that reduces the level of binding of HTT mRNA to the MID1 protein in vitro. The obtained results introduce aurones as a novel platform for the design of functional ligands for disease-related RNA sequences.},
keywords = {Huntingtin RNA–protein interaction},
pubstate = {published},
tppubtype = {article}
}