@article{RN13761,
title = {Analyses of ecdysteroid transporters in the fat body of Tribolium castaneum},
author = {B Wellmeyer and A C Böhringer and J Rösner and H Merzendorfer},
doi = {10.1111/imb.12839},
issn = {0962-1075},
year = {2023},
date = {2023-01-01},
journal = {Insect Mol Biol},
keywords = {Tribolium castaneum},
pubstate = {published},
tppubtype = {article}
}

@article{Qu2021,
title = {Bioinsecticides as future mainstream pest control agents: Opportunities and challenges},
author = {Mingbo Qu and Hans Merzendorfer and Bernard Moussian and Qing Yang},
editor = {Front J},
url = { https://doi.org/10.15302/J-FASE-2021404 },
doi = {10.15302/J-FASE-2021404 },
isbn = {2095-7505},
year = {2021},
date = {2021-06-04},
journal = {Front. Agr. Sci. Eng.},
volume = {404},
number = {0},
pages = {1-17},
abstract = {Bioinsecticides are naturally occurring substances from different sources that control insect pests. Ideal bioinsecticides should exhibit low toxicity to non-target organisms. Further, they should be easily degraded in sewage plants and natural environments, highly effective in small quantities and only affect target pests. Public concerns about possible side-effects of conventional pesticides has accelerated bioinsecticide research and development. However, to develop bioinsecticides into a mainstream product line, the high production costs, short shelflife and uncertain acting modes of many bioinsecticides need to be considered. In this review, we summarize current progress on bioinsecticides, which are categorized into three classes, i.e. biochemical insecticides and their derivatives, plant-incorparated protectants (PIPs), and microbial bioinsecticides. The shortcomings that prevent bioinsecticides from being widely applied are discussed, and the future research direction in the field is proposed.},
note = {na},
keywords = {Tribolium castaneum},
pubstate = {published},
tppubtype = {article}
}

@article{https://doi.org/10.1002/ps.6332,
title = {Functional analysis of ABCG and ABCH transporters from the red flour beetle, Tribolium castaneum},
author = {Janin Rösner and Johanne Tietmeyer and Hans Merzendorfer},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/ps.6332},
doi = {https://doi.org/10.1002/ps.6332},
year = {2021},
date = {2021-01-01},
journal = {Pest Management Science},
volume = {77},
number = {6},
pages = {2955-2963},
abstract = {Abstract BACKGROUND ATP-binding cassette transporter (ABC transporter) subfamilies ABCA–C and ABCG–H have been implicated in insecticide detoxification, mostly based on findings of elevated gene expression in response to insecticide treatment. We previously characterized TcABCA–C genes from the model beetle and pest Tribolium castaneum and demonstrated that TcABCA and TcABCC genes are involved in the elimination of diflubenzuron, because RNA interference (RNAi)-mediated gene silencing increased susceptibility. In this study, we focused on the potential functions of TcABCG and TcABCH genes in insecticide detoxification. RESULTS When we silenced the expression of TcABCG–H genes using RNAi, we noticed a previously unreported developmental RNAi phenotype for TcABCG-4F, which is characterized by 50% mortality and ecdysial arrest during adult moult. When we knocked down the Drosophila brown orthologue TcABCG-XC, we did not obtain apparent eye colour phenotypes but did observe a loss of riboflavin uptake by Malpighian tubules. Next, we determined the expression profiles of all TcABCG–H genes in different tissues and developmental stages and analysed transcript levels in response to treatment with four chemically unrelated insecticides. We found that some genes were specifically upregulated after insecticide treatment. However, when we determined insecticide-induced mortalities in larvae that were treated by double-stranded RNA injection to silence those TcABCG–H genes that were upregulated, we did not observe a significant increase in susceptibility to insecticides. CONCLUSION Our findings suggest that the observed insecticide-dependent induction of TcABCG–H gene expression reflects an unspecific stress response, and hence underlines the significance of functional studies on insecticide detoxification. © 2021 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.},
keywords = {ATP-binding cassette transporters (ABC transporter), diflubenzuron, insecticide detoxification, malathion, tebufenozide, Tribolium castaneum, β-cyfluthrin},
pubstate = {published},
tppubtype = {article}
}